NGB and GNAI3

Data Source:
HPRD (in vitro)

		NGB	GNAI3
Description		neuroglobin	G protein subunit alpha i3
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GO Annotations	Cellular Component	Mitochondrion Cytosol Perikaryon	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Oxygen Transport	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Intracellular oxygen transport	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS			Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		21 interacting genes: AKT1 ATP1B2 BTBD2 C1orf94 DDIT4L FLOT1 GATAD2B GNAI1 GNAI2 GNAI3 GNAO1 IHO1 L3MBTL3 MEI4 NIF3L1 PTEN REL TDO2 TEPSIN VAC14 ZNF655	43 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		58157	2773
HPRD ID		05602	00765
Ensembl ID		ENSG00000165553	ENSG00000065135
Uniprot IDs		A0M8W9 Q9NPG2	P08754
PDB IDs		1OJ6 4MPM	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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