PTPRJ and LAT

Data Source:
HPRD (in vitro)

		PTPRJ	LAT
Description		protein tyrosine phosphatase receptor type J	linker for activation of T cells
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Ruffle Membrane Specific Granule Membrane Extracellular Exosome	Immunological Synapse Golgi Apparatus Plasma Membrane COP9 Signalosome Integral Component Of Membrane Membrane Raft
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion B Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	MAPK Cascade Adaptive Immune Response Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 29235454) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		36 interacting genes: ANP32B BAAT BAP1 CASC3 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 FANCC FBP1 HEMGN HOXC6 HRAS IL2RG JUP KLK7 KLK9 LAT LYPD3 MAP2K1 MET NANS NOP2 PDGFRB PLCG1 PPP2CB PPP3R2 PRDM14 RASA1 SDCBP SFRP4 TMEFF1 TRMO TSTD2 ZNF510	95 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MFSD14B MFSD5 MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35C2 SLC51B SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2
Entrez ID		5795	27040
HPRD ID		02955	03832
Ensembl ID		ENSG00000149177	ENSG00000213658
Uniprot IDs		Q12913 Q9NPR5	A0A024QZD6 O43561
PDB IDs		2CFV 2DLE 2NZ6
Enriched GO Terms of Interacting Partners?
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