PTPRF and ROCK2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PTPRF	ROCK2
Description		protein tyrosine phosphatase receptor type F	Rho associated coiled-coil containing protein kinase 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Neuronal Cell Body Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Heparin Binding Chondroitin Sulfate Proteoglycan Binding Protein-containing Complex Binding Cell Adhesion Molecule Binding	RNA Binding Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Migration Neuron Projection Regeneration Peptidyl-tyrosine Dephosphorylation Regulation Of Axon Regeneration Synaptic Membrane Adhesion Negative Regulation Of Receptor Binding	Mitotic Cytokinesis Positive Regulation Of Protein Phosphorylation Response To Ischemia Aortic Valve Morphogenesis Protein Phosphorylation Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Rho Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Regulation Of Nervous System Process Positive Regulation Of Connective Tissue Growth Factor Production Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Myosin-light-chain-phosphatase Activity Viral RNA Genome Replication Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Rhythmic Process Embryonic Morphogenesis Regulation Of Protein Metabolic Process Centrosome Duplication Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Cellular Response To Testosterone Stimulus Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Positive Regulation Of Fibroblast Growth Factor Production Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Regulation Of Cellular Response To Hypoxia Regulation Of Cell Junction Assembly Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Cellular Response To Acetylcholine Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHOBTB1 GTPase cycle Potential therapeutics for SARS
Drugs			Fasudil Y-27632 Fostamatinib Ripasudil Netarsudil
Diseases
GWAS		Adventurousness ( 30643258) Amyotrophic lateral sclerosis (age of onset) ( 22959728) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Coffee consumption ( 31046077) Cognitive ability (MTAG) ( 29186694) Educational attainment ( 27046643) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Intake of total sugars ( 31005972) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Stroke ( 29531354) Urate levels ( 31578528)	LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494)
Interacting Genes		59 interacting genes: ACAN ACAT1 ACTB ARHGEF11 ARHGEF12 ARHGEF2 ATP5F1A BCAR1 CAV1 CBR1 CDH1 CREBBP CTNNB1 DEPDC1B DIAPH1 EEF1A1 EEF1G FRS2 FYN GALNT1 GAPDH GPC4 HSP90AA1 HSPA1A HSPA1L HSPA5 HSPA8 HSPA9 INSR IRS1 IRS2 JUP LACTB LCK LDHA LDHB NCAN NID1 PPFIA1 PPFIA2 PPFIA3 PRPF40A PTPRA PTPRD PTPRZ1 RAP1GDS1 RET RHOA ROCK2 SEMG1 SEMG2 SEPTIN9 SKIL SOWAHC TRIO TUBA1B TUBB4B VCAN ZNF512B	5 interacting genes: CDKN3 MAGEC1 PPP1R12A PTPRF STAU1
Entrez ID		5792	9475
HPRD ID		01552	04922
Ensembl ID		ENSG00000142949	ENSG00000134318
Uniprot IDs		G1UI20 P10586	A0A2P9DU05 O75116 Q14DU5
PDB IDs		1LAR 2DJU 2DN7 2EDX 2EDY 2YD5 2YD8 4N5U 6KR4 6TPT 6TPU 6TPV 6TPW	4L6Q 4WOT 5U7Q 5U7R 6ED6 6P5M 6P5P 7JNT 7JOV
Enriched GO Terms of Interacting Partners?
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