MARK4 and MAP4

Data Source:
HPRD (in vitro)

		MARK4	MAP4
Description		microtubule affinity regulating kinase 4	microtubule associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Neuron Projection	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Microtubule Cytoskeleton Axon Neuron Projection Mitotic Spindle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Structural Molecule Activity Protein Binding Microtubule Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Cell Cycle Nervous System Development Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Regulation Of Centrosome Cycle Cell Division Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Neuron Projection Development Microtubule Sliding Establishment Of Spindle Orientation Cell Division Negative Regulation Of Non-motile Cilium Assembly
Pathways		Anchoring of the basal body to the plasma membrane
Drugs		Fostamatinib	Paclitaxel Docetaxel Artenimol
Diseases
GWAS		Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (father's attained age) ( 29227965) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549) White blood cell count ( 32888494 27863252)	Blood pressure ( 21909110) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 27841878 28739976 27618452) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean arterial pressure ( 27618448) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976 27618452 30578418)
Interacting Genes		30 interacting genes: APLNR CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MED20 MTUS2 NEDD4 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ	23 interacting genes: CCNB1 CDC42 CDK1 CLASP1 ENO2 ERBIN GSK3B IL7R LDLR MARK1 MARK4 NOP58 NR1I3 POT1 RXRB RXRG SNTA1 SRPK2 STRBP SUMO2 TERF1 TUBB UBC
Entrez ID		57787	4134
HPRD ID		09402	01141
Ensembl ID		ENSG00000007047	ENSG00000047849
Uniprot IDs		Q96L34	P27816
PDB IDs		5ES1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?