ANKRA2 and MPL

Data Source:
BioGRID (unspecified method)

		ANKRA2	MPL
Description		ankyrin repeat family A member 2	MPL proto-oncogene, thrombopoietin receptor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Membrane Protein-containing Complex 3M Complex	Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Thrombopoietin Receptor Activity
	Biological Process	Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly	Neutrophil Homeostasis Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Platelet Aggregation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis
Pathways			Platelet Aggregation (Plug Formation)
Drugs			Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases			Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Monobrow thickness ( 26926045)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: ABL1 APP CDKN2A HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX7 SAMD4A TSHZ3	9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		57763	4352
HPRD ID		12044	01161
Ensembl ID		ENSG00000164331	ENSG00000117400
Uniprot IDs		A0A024RAN7 Q9H9E1	P40238
PDB IDs		3SO8 3V2O 3V2X 3V31 4LG6 4QQI
Enriched GO Terms of Interacting Partners?
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