TRIB3 and HLA-B

Data Source:
BioGRID (two hybrid)

		TRIB3	HLA-B
Description		tribbles pseudokinase 3	major histocompatibility complex, class I, B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	Signaling Receptor Binding Protein Binding Peptide Antigen Binding TAP Binding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Regulation Of Autophagy Regulation Of Glucose Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Positive Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Viral Process Detection Of Bacterium Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Dendritic Cell Differentiation
Pathways		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs			Abacavir N-Formylmethionine Coccidioides immitis spherule
Diseases
GWAS		Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 32492107 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Ankylosing spondylitis ( 21743469 30946743) Anti-thyroid drug induced agranulocytosis ( 27157822) Apolipoprotein A1 levels ( 32203549) Asthma ( 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Behcet's disease ( 24326010 27548383) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 29875488 28240269) Body fat percentage variance ( 31453325) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Cardiometabolic and hematological traits ( 27668658) CD4:CD8 lymphocyte ratio ( 20045101) CD8-positive T-lymphocyte count ( 20045101) Cervical cancer ( 23482656 28806749) Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide) ( 25813999) Chickenpox ( 28928442) Clozapine-induced agranulocytosis ( 25187353) Cold sores ( 28928442) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Crohn's disease ( 26891255) Diastolic blood pressure ( 25249183) Diffuse large B cell lymphoma ( 25261932) Drug-induced liver injury (flucloxacillin) ( 19483685 30661239) Eosinophil counts ( 29403010) Eosinophil percentage of white cells ( 27863252) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate in diabetes ( 31451708) Frontal fibrosing alopecia ( 30850646) Gastroesophageal reflux disease ( 31527586) Giant cell arteritis ( 28041642) Graves' disease ( 21841780) HDL cholesterol levels ( 32203549) Height ( 19343178 23563607 31562340) Hemoglobin levels ( 32327693) HIV-1 control ( 21051598 20041166) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 20205591 26039976) Hypothyroidism ( 22493691) IgA nephropathy ( 26028593) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol levels ( 32203549) Leukoderma in response to rhododendrol ( 32558222) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Marginal zone lymphoma ( 25569183) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 27863252) Mean reticulocyte volume ( 32888494) Medication use (salicylic acid and derivatives) ( 31015401) Metabolic syndrome ( 31589552) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 22190364 19525953) Myositis ( 26291516) Nasal polyps ( 30643255) Nasopharyngeal carcinoma ( 20512145) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010) Neutrophil percentage of white cells ( 32888494) Nevirapine-induced hypersensitivity in HIV ( 28062682) Non-albumin protein levels ( 29403010) Peripheral artery disease ( 31285632) Plantar warts ( 28928442) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pneumonia ( 28928442) Pre-treatment viral load in HIV-1 infection ( 31219150) Primary sclerosing cholangitis ( 23603763) Proliferative diabetic retinopathy ( 31482010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Red blood cell count ( 32888494) Rheumatic heart disease ( 32488134) Rheumatoid arthritis (ACPA-negative) ( 24532677) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum albumin level ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severe aplastic anemia ( 32004448) Shingles ( 30298529 25297839 28928442) Small cell lung carcinoma ( 28604730) Strep throat ( 28928442) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 26606652 28714469) Systolic blood pressure ( 25249183) Takayasu arteritis ( 25604533 30498034 23830517) Tonsillectomy ( 28928442) Trichloroethylene-induced hypersensitivity syndrome ( 26190474) Triglyceride levels ( 32203549) Tuberculosis ( 28928442) Type 2 diabetes ( 25102180) Ulcerative colitis ( 28067908) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) White blood cell count ( 25096241 29403010 32888494 21738480) White blood cell count (basophil) ( 27863252) White matter integrity (mean diffusivity) ( 32358547)
Interacting Genes		99 interacting genes: AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MISP OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PML PPP1R26 PPP1R32 PRKAB2 PRMT5 PRR19 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SQSTM1 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587	16 interacting genes: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3
Entrez ID		57761	3106
HPRD ID		09836	00828
Ensembl ID		ENSG00000101255	ENSG00000234745
Uniprot IDs		B4DMM9 J3KR25 Q96RU7	E5FQ95 P01889
PDB IDs			1A1M 1A1N 1A1O 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1CG9 1E27 1E28 1HSA 1JGD 1JGE 1K5N 1M05 1M6O 1MI5 1N2R 1OF2 1OGT 1SYS 1SYV 1UXS 1UXW 1W0V 1W0W 1XH3 1XR8 1XR9 1ZHK 1ZHL 1ZSD 2A83 2AK4 2AXF 2AXG 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2H6P 2HJL 2NW3 2NX5 2RFX 2YPK 2YPL 3B3I 3B6S 3BP4 3BP7 3BW9 3BWA 3C9N 3CZF 3D18 3DTX 3DX6 3DX7 3DX8 3DXA 3FFC 3HCV 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LV3 3MV7 3MV8 3MV9 3SJV 3SKM 3SKO 3SPV 3UPR 3VCL 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3W39 3WUW 3X11 3X12 3X13 3X14 4G8G 4G8I 4G9D 4G9F 4JQV 4JQX 4LCY 4LNR 4MJI 4O2C 4O2E 4O2F 4PR5 4PRN 4QRP 4QRQ 4QRR 4QRS 4QRT 4QRU 4U1H 4U1I 4U1J 4U1K 4U1L 4U1M 4U1N 4U1S 4XXC 5B38 5B39 5DEF 5DEG 5EO0 5EO1 5IB1 5IB2 5IB3 5IB4 5IB5 5IEH 5IEK 5IM7 5INC 5IND 5T6W 5T6X 5T6Y 5T6Z 5T70 5TXS 5U98 5V5L 5V5M 5VUD 5VUE 5VUF 5VWD 5VWF 5VWH 5VWJ 5VZ5 5WMN 5WMO 5WMP 5WMQ 5WMR 5XOS 5XOT 6AT5 6AVF 6AVG 6BJ2 6BJ3 6BJ8 6BXP 6BXQ 6D29 6D2B 6D2R 6D2T 6MT3 6MT4 6MT5 6MT6 6MTL 6MTM 6P23 6P27 6P2C 6P2F 6P2S 6PYJ 6PYL 6PYV 6PYW 6PZ5 6VMX
Enriched GO Terms of Interacting Partners?
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