SLC7A14 and DERL1

Data Source:
BioGRID (two hybrid)

		SLC7A14	DERL1
Description		solute carrier family 7 member 14	derlin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Cytosol Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Amino Acid Transmembrane Transport Amino Acid Transport Negative Regulation Of Phosphatase Activity	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process
Pathways			ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Obesity (extreme) ( 30677029) Spontaneous preterm birth without premature rupture of membranes ( 31194736)	Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		47 interacting genes: ACSL5 ADGRE2 AGTRAP AIG1 APOL3 BET1 BNIP1 BNIP2 C1GALT1 CBLIF CCDC167 CCL4L2 CD53 CMTM5 DCBLD2 DERL1 EOGT ERMP1 FAM209A FAM20B FATE1 FCER1G FKBP7 IL10RA LINC00839 LTC4S MFF MGLL MMGT1 NINJ2 NSG1 PLPP6 PRB1 SCARF1 SCD SMCO4 TECR TMEM128 TMEM31 TRARG1 TREX1 UBIAD1 VAMP2 VKORC1 YIPF4 YIPF6 ZFPL1	33 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBE2J1 UBXN6 VCP
Entrez ID		57709	79139
HPRD ID		17222	12302
Ensembl ID		ENSG00000013293	ENSG00000136986
Uniprot IDs		Q8TBB6	A0A024R9G3 E5RGY0 Q9BUN8
PDB IDs			5GLF
Enriched GO Terms of Interacting Partners?
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