CHD8 and TOP3B

Data Source:
HPRD (two hybrid)

		CHD8	TOP3B
Description		chromodomain helicase DNA binding protein 8	DNA topoisomerase III beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex	Condensed Chromosome Nucleus
	Molecular Function	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	DNA Topological Change Chromosome Segregation
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Height ( 31562340)	Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		11 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 SUMO2 TOP3B WDR5	24 interacting genes: ADAMTSL4 AXIN2 BHLHB9 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF250 ZNF408
Entrez ID		57680	8940
HPRD ID		16712	04662
Ensembl ID		ENSG00000100888	ENSG00000100038
Uniprot IDs		Q9HCK8	A0A024R1C2 A8K4N2 O95985
PDB IDs		2CKA 2DL6	5GVC 5GVE
Enriched GO Terms of Interacting Partners?
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