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HOMEZ and PRKAA1
Data Source:
BioGRID
(two hybrid)
HOMEZ
PRKAA1
Description
homeobox and leucine zipper encoding
protein kinase AMP-activated catalytic subunit alpha 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Apical Plasma Membrane
Nuclear Speck
Axon
Dendrite
Nucleotide-activated Protein Kinase Complex
Neuronal Cell Body
Molecular Function
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Histone Serine Kinase Activity
Protein-containing Complex Binding
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Tau Protein Binding
Tau-protein Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Activation Of MAPK Activity
Response To Hypoxia
Glucose Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Cell Cycle Arrest
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Lipid Biosynthetic Process
Response To UV
Cold Acclimation
Response To Gamma Radiation
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Response To Activity
Bile Acid And Bile Salt Transport
Wnt Signaling Pathway
Macroautophagy
Regulation Of Macroautophagy
Fatty Acid Oxidation
Response To Caffeine
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Oxidative Stress
Histone-serine Phosphorylation
Intracellular Signal Transduction
Cellular Response To Drug
Bile Acid Signaling Pathway
Cellular Response To Glucose Starvation
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Glycolytic Process
Negative Regulation Of Glucosylceramide Biosynthetic Process
Negative Regulation Of Insulin Receptor Signaling Pathway
Rhythmic Process
Positive Regulation Of Skeletal Muscle Tissue Development
Negative Regulation Of Lipid Catabolic Process
Fatty Acid Homeostasis
Regulation Of Vesicle-mediated Transport
Motor Behavior
CAMKK-AMPK Signaling Cascade
Regulation Of Stress Granule Assembly
Neuron Cellular Homeostasis
Cellular Response To Hydrogen Peroxide
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Ethanol
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Organonitrogen Compound
Cellular Response To Hypoxia
Energy Homeostasis
Regulation Of Bile Acid Secretion
Response To Camptothecin
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Mitochondrial Transcription
Positive Regulation Of Cellular Protein Localization
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Tubulin Deacetylation
Response To 17alpha-ethynylestradiol
Positive Regulation Of Peptidyl-lysine Acetylation
Pathways
Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Activation of AMPK downstream of NMDARs
Drugs
Adenosine phosphate
Adenosine phosphate
ATP
Phenformin
Acetylsalicylic acid
Fostamatinib
Fostamatinib
Diseases
GWAS
Height (
31562340
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean platelet volume (
32888494
)
Pulse pressure (
27841878
)
Reticulocyte count (
32888494
)
Systolic blood pressure (
27841878
)
Cardia gastric cancer (
26129866
)
Gastric cancer (
22037551
26098866
26129866
31383772
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Non-cardia gastric cancer (
26701879
26129866
)
Interacting Genes
114 interacting genes:
ACTR10
AEN
ANKRD11
ANKRD2
ARHGAP9
ASB6
AXIN1
BIVM
BYSL
C2orf42
CBX8
CCDC13
CCDC187
CCHCR1
CCNK
CDC7
CENPS
CENPS-CORT
CFAP206
CTNNA3
DEF6
DGCR6
DHX16
DNTTIP1
EBF1
EIF4E2
ELOA
ENKD1
FAM90A1
FARS2
GAS8
GFAP
GPANK1
GRB2
HOXC8
HSF2BP
IL16
INO80B
JAKMIP2
KIFC3
KPNA2
LENG1
LGALS4
LMO1
LMO3
LNX1
LRRC7
LSM4
MAD2L1BP
MAFG
MAPK1
MED18
MORF4L2
MOS
MRPL11
NCK1
NCK2
NEIL2
NEK6
NXF1
OSGIN1
PARVG
PHF1
PHF19
PIBF1
PIN1
PLEKHA7
POLDIP3
PRKAA1
PRKAA2
PRPF18
PSMA1
RASL10A
RBM39
RNF8
RPGR
RPL9
RPP25
RPS25
SCNM1
SDCBP
SEC23A
SH3RF2
SMARCB1
SMARCD1
SMYD1
SNRPB2
SUMO2
SUMO3
TARS2
TBC1D30
TCEA2
TCEANC
TEAD4
TLE5
TRAF4
TSGA10IP
TXK
USF1
VEZF1
VPS9D1
ZBTB25
ZBTB7A
ZMYND19
ZNF165
ZNF250
ZNF280C
ZNF35
ZNF417
ZNF580
ZNF629
ZNF688
ZNF76
ZSCAN5B
67 interacting genes:
ABI2
ACACA
BHLHE40
CAB39
CAMKK1
CDX4
CFTR
CHEK1
CRTC2
CTBP1
DVL2
EEF2K
EPM2A
FANCA
FNIP1
GATA1
GOLGA2
GRIK2
HDAC5
HMBOX1
HOMEZ
IKZF3
INO80E
KIF16B
KRT40
L3MBTL3
MDM4
MORC4
MTOR
MTUS2
PASK
PFKFB2
PHC2
PNMA5
PPM1A
PPM1E
PPM1F
PPP2CA
PRKAB1
PRKAB2
PRKAG1
PRKAG3
PSMD11
RACK1
RAD54B
RAF1
RBPMS
RFX6
RIMBP3
ROPN1
RPTOR
SRPK2
SSX2IP
STK11
THAP1
TLE5
TOMM34
TRIM27
TRIP6
TSC2
TSC22D4
TXNIP
UBXN11
ULK1
VPS37B
VPS52
ZBED1
Entrez ID
57594
5562
HPRD ID
12167
04115
Ensembl ID
ENSG00000215271
ENSG00000132356
Uniprot IDs
Q8IX15
Q13131
PDB IDs
2ECC
2YS9
4RED
4RER
4REW
5EZV
6C9F
6C9G
6C9H
6C9J
Enriched GO Terms of Interacting Partners
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