KLHL8 and CA8

Data Source:
BioGRID (two hybrid)

		KLHL8	CA8
Description		kelch like family member 8	carbonic anhydrase 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cul3-RING Ubiquitin Ligase Complex	Cytoplasm
	Molecular Function		Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination	One-carbon Metabolic Process Phosphatidylinositol-mediated Signaling
Pathways
Drugs			Zonisamide
Diseases
GWAS		Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010) Triglycerides ( 24097068 25961943 20686565)	Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 28991256 25056061 29483656 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7	14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3
Entrez ID		57563	767
HPRD ID		13928	00266
Ensembl ID		ENSG00000145332	ENSG00000178538
Uniprot IDs		B3KY78 Q68DU9 Q7Z330 Q9P2G9	P35219
PDB IDs			2W2J
Enriched GO Terms of Interacting Partners?
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