PTH and MEP1A

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		PTH	MEP1A
Description		parathyroid hormone	meprin A subunit alpha
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Integral Component Of Plasma Membrane Meprin A Complex Extracellular Exosome
	Molecular Function	Hormone Activity Protein Binding Parathyroid Hormone Receptor Binding Type 1 Parathyroid Hormone Receptor Binding Protein N-terminus Binding Receptor Ligand Activity Peptide Hormone Receptor Binding	Metalloendopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Rho Protein Signal Transduction Cell-cell Signaling Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Magnesium Ion Homeostasis Positive Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Response To Vitamin D Cellular Macromolecule Biosynthetic Process Response To Drug Bone Resorption Response To Ethanol Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II CAMP Metabolic Process Positive Regulation Of Glucose Import Response To Cadmium Ion Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Calcium Ion Transport Phosphate Ion Homeostasis Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Parathyroid Hormone Response To Fibroblast Growth Factor Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Bone Mineralization Involved In Bone Maturation	Proteolysis
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		D-norleucine ABX-PTH
Diseases
GWAS		Bone mineral density ( 19874204) Childhood ear infection ( 27182965) Menarche (age at onset) ( 25231870) Progression free survival in serous epithelial ovarian cancer treated with carboplatin and paclitaxel ( 28935272)
Interacting Genes		6 interacting genes: ASPH BAG6 FEZ1 MEP1A PTH1R PTH2R	18 interacting genes: AGT CCK FN1 GCG GNRH1 GRP KNG1 LAMA1 LAMA5 MEP1B NPY NTS PLG POMC PTH SCT TAC1 VIP
Entrez ID		5741	4224
HPRD ID		01345	02666
Ensembl ID		ENSG00000152266	ENSG00000112818
Uniprot IDs		P01270	B7ZL91 Q16819
PDB IDs		1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG 2L1X 3C4M
Enriched GO Terms of Interacting Partners?
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