BAD and RPS6KA2

Data Source:
HPRD (in vitro, in vivo)

		BAD	RPS6KA2
Description		BCL2 associated agonist of cell death	ribosomal protein S6 kinase A2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Phosphatase 2B Binding Protein Kinase B Binding 14-3-3 Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Release Of Cytochrome C From Mitochondria Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Glucose Catabolic Process Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Glucose Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Cerebral Cortex Development Positive Regulation Of Insulin Secretion Response To Estradiol Response To Progesterone Positive Regulation Of Glucokinase Activity Response To Testosterone Response To Oleic Acid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Drug Response To Hydrogen Peroxide Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Type B Pancreatic Cell Proliferation Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Positive Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Response To Calcium Ion Positive Regulation Of Apoptotic Process By Virus Cellular Response To Chromate Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Response To Benzene Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Granulosa Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Signal Transduction Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle
Pathways		Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Navitoclax
Diseases
GWAS		Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) Dental caries ( 23259602) Inflammatory bowel disease ( 27569725 23128233) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)
Interacting Genes		45 interacting genes: ACTN2 AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	12 interacting genes: BAD CREB1 FLNC FOS JUN L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 SHANK1 TP53
Entrez ID		572	6196
HPRD ID		04409	03403
Ensembl ID		ENSG00000002330	ENSG00000071242
Uniprot IDs		A0A024R562 Q92934	B7Z3B5 Q15349 X5D337
PDB IDs		1G5J
Enriched GO Terms of Interacting Partners?
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