RTN4 and LRCH4

Data Source:
HPRD (two hybrid)

		RTN4	LRCH4
Description		reticulon 4	leucine rich repeats and calponin homology domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	PML Body
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Protein Binding
	Biological Process	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve	Nervous System Development
Pathways		Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Obesity (extreme) ( 19553259) Platelet count ( 32888494) Systolic blood pressure ( 30224653)	Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		47 interacting genes: BAIAP2 BCL2 BCL2L1 BDKRB1 CCR4 CERT1 CHRM4 CLN8 CNTNAP1 CRMP1 CYSLTR2 DRD2 ERBB2 ERBB3 ERBB4 F2RL1 FXR2 GLP1R GPR35 HLA-DPB1 HTR2C LAMA4 LINC01554 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 PLEKHF2 POT1 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	16 interacting genes: CA8 CYB5R3 ELOVL7 HSD17B11 KASH5 KRT40 KRTAP10-7 KRTAP10-8 MDFI NOTCH2NLA RBBP6 RETREG3 RNASEK RTN4 SIN3A SPOP
Entrez ID		57142	4034
HPRD ID		07259	10062
Ensembl ID		ENSG00000115310	ENSG00000077454
Uniprot IDs		Q9NQC3	O75427
PDB IDs		2G31 2JV5
Enriched GO Terms of Interacting Partners?
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