KNL1 and PAK6

Data Source:
BioGRID (genetic interference)

		KNL1	PAK6
Description		kinetochore scaffold 1	p21 (RAC1) activated kinase 6
Image
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Nuclear Body	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Acrosome Assembly Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Activation of RAC1
Drugs			Fostamatinib
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK	20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1
Entrez ID		57082	56924
HPRD ID		10634	06426
Ensembl ID		ENSG00000137812	ENSG00000137843
Uniprot IDs		Q8NG31	A0A024R9Q4 Q9NQU5
PDB IDs		3SI5 4A1G 4NF9 4NFA	2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?