PAK6 and RHOV

Data Source:
BioGRID (two hybrid)

		PAK6	RHOV
Description		p21 (RAC1) activated kinase 6	ras homolog family member V
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction	Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Neuron Projection Arborization Neuron Projection Extension	Endocytosis Cell Migration Cell Projection Assembly Cdc42 Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Activation of RAC1	Rho GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		20 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 TPD52L1	1 interacting genes: PAK6
Entrez ID		56924	171177
HPRD ID		06426	10191
Ensembl ID		ENSG00000137843	ENSG00000104140
Uniprot IDs		A0A024R9Q4 Q9NQU5	A0A024R9R2 Q96L33
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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