PSMC5 and HTT

Data Source:
BioGRID (pull down)

		PSMC5	HTT
Description		proteasome 26S subunit, ATPase 5	huntingtin
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytoplasmic Vesicle Nuclear Proteasome Complex Cytosolic Proteasome Complex Extracellular Exosome Blood Microparticle Postsynapse	Nucleus Nucleoplasm Cytoplasm Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Binding ATP Binding Transcription Factor Binding ATPase Activity TBP-class Protein Binding Thyrotropin-releasing Hormone Receptor Binding	P53 Binding Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Apoptotic Process Golgi Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Microtubule-based Transport Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Regulation of MECP2 expression and activity
Drugs			Copper
Diseases			Huntington's disease (HD)
GWAS			Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean platelet volume ( 32888494) Monobrow ( 27182965) Neutrophil count ( 32888494) Parental lifespan ( 30642433) Platelet count ( 32888494) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) White blood cell count ( 32888494) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		80 interacting genes: AKT1 AZIN2 BACH2 BFSP2 CAMK2A CCDC136 CDC42 CFAP206 EPHA8 ERCC3 ERCC6 ESR1 ESR2 ESRRA ESRRG FOS GTF2B HARS1 HNF4G HOMER3 HSPA1A HTT INSIG2 KRT15 KRT27 KRT31 KRT38 KRT40 LAMB1 LAMC1 MDM2 MYO18B NR1H3 NR1I2 NR1I3 NR3C2 PDC PDCL PLEKHO1 PPARD PRKN PSMC1 PSMC2 PSMC3 PSMC4 PSMC6 PSMD11 PSMD12 RAD23A RARA RARB RARG RORA RORB RORC RXRA SCOC SHOC2 SIRPA SKA1 SP1 SSNA1 SUMO2 TAF10 TFIP11 THAP11 THRB TNNI2 TNNI3 TNNT1 TP53 TPM1 TPM3 TRIP11 UBC UBE3C UBLCP1 USP4 VDR VIM	110 interacting genes: AKT1 AMFR AP2A2 BDKRB1 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		5705	3064
HPRD ID		03400	00883
Ensembl ID		ENSG00000087191	ENSG00000197386
Uniprot IDs		A0A140VJS3 P62195	P42858
PDB IDs		2KRK 3KW6 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN	2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C 6RMH 6X9O
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?