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PSMB2 and KRTAP19-5
Data Source:
BioGRID
(two hybrid)
PSMB2
KRTAP19-5
Description
proteasome 20S subunit beta 2
keratin associated protein 19-5
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Membrane
Proteasome Core Complex, Beta-subunit Complex
Extracellular Exosome
Cytosol
Intermediate Filament
Molecular Function
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Protein Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Response To Organonitrogen Compound
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Response To Organic Cyclic Compound
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Keratinization
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Keratinization
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Carfilzomib
Diseases
GWAS
Interacting Genes
14 interacting genes:
AXIN2
DDX49
GPX2
HSPB1
INCA1
KCTD9
KRT13
KRTAP19-1
KRTAP19-5
KRTAP19-6
KRTAP19-7
PLK1
PSMA1
PSMB3
97 interacting genes:
ANKHD1
APOBEC1
ARID5A
ATN1
ATPAF2
BHLHE40
C11orf16
C9orf24
CAMK2A
CAMK2B
CATSPER1
CCDC17
CELF5
CHRD
COL8A1
CRACR2A
CREB5
CRYAB
CYSRT1
DAB1
DAZAP2
DMRT3
DMRTB1
EFEMP2
ENKD1
ESRP1
EVX2
FAM168A
FAM214B
GLIS2
GLYCTK
GPANK1
GRINA
GUCD1
HAPLN2
HGS
HOXB9
HYPK
INCA1
KIFC3
KPRP
KRT34
KRTAP12-4
KRTAP15-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
MAGED1
MAPK1IP1L
MGAT5B
MYOZ3
MYPOP
OIP5
OLIG3
OXER1
P4HA3
PATZ1
PITX1
PITX2
PLSCR4
POU2AF1
PPP1R16A
PPP1R32
PRKAG3
PRPF31
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMA3
PSMB2
PSMB4
RBPMS
RBPMS2
RHOXF2
RNF38
RNF44
RTP5
RUSC1
SEMA3B
SNRPC
SOHLH1
TCF7L2
TEKT3
TEX37
TLE5
TNIP1
TSPYL6
UBQLN2
VAC14
VEZF1
VPS37C
ZBTB32
ZIC1
ZNF414
Entrez ID
5690
337972
HPRD ID
03708
11209
Ensembl ID
ENSG00000126067
ENSG00000186977
Uniprot IDs
A0A087WVV1
A0A140VJS6
B7Z478
P49721
Q3LI72
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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