PSMB2 and KRTAP19-5

Data Source:
BioGRID (two hybrid)

		PSMB2	KRTAP19-5
Description		proteasome 20S subunit beta 2	keratin associated protein 19-5
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Membrane Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome	Cytosol Intermediate Filament
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding	Protein Binding
	Biological Process	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Response To Organonitrogen Compound Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Organic Cyclic Compound Viral Process Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation	Keratinization
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Keratinization
Drugs		(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib
Diseases
GWAS
Interacting Genes		14 interacting genes: AXIN2 DDX49 GPX2 HSPB1 INCA1 KCTD9 KRT13 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 PLK1 PSMA1 PSMB3	97 interacting genes: ANKHD1 APOBEC1 ARID5A ATN1 ATPAF2 BHLHE40 C11orf16 C9orf24 CAMK2A CAMK2B CATSPER1 CCDC17 CELF5 CHRD COL8A1 CRACR2A CREB5 CRYAB CYSRT1 DAB1 DAZAP2 DMRT3 DMRTB1 EFEMP2 ENKD1 ESRP1 EVX2 FAM168A FAM214B GLIS2 GLYCTK GPANK1 GRINA GUCD1 HAPLN2 HGS HOXB9 HYPK INCA1 KIFC3 KPRP KRT34 KRTAP12-4 KRTAP15-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 MAGED1 MAPK1IP1L MGAT5B MYOZ3 MYPOP OIP5 OLIG3 OXER1 P4HA3 PATZ1 PITX1 PITX2 PLSCR4 POU2AF1 PPP1R16A PPP1R32 PRKAG3 PRPF31 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 PSMB2 PSMB4 RBPMS RBPMS2 RHOXF2 RNF38 RNF44 RTP5 RUSC1 SEMA3B SNRPC SOHLH1 TCF7L2 TEKT3 TEX37 TLE5 TNIP1 TSPYL6 UBQLN2 VAC14 VEZF1 VPS37C ZBTB32 ZIC1 ZNF414
Entrez ID		5690	337972
HPRD ID		03708	11209
Ensembl ID		ENSG00000126067	ENSG00000186977
Uniprot IDs		A0A087WVV1 A0A140VJS6 B7Z478 P49721	Q3LI72
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ
Enriched GO Terms of Interacting Partners?
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