KLK6 and SERPINC1

Data Source:
HPRD (in vitro)

		KLK6	SERPINC1
Description		kallikrein related peptidase 6	serpin family C member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Secretory Granule	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding
	Biological Process	Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway	Acute Inflammatory Response To Antigenic Stimulus Response To Nutrient Lactation Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Blood Coagulation, Intrinsic Pathway
Pathways			Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Benzamidine	Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases			Inherited thrombophilia
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549)
Interacting Genes		7 interacting genes: LSP1 PALB2 PAX2 SERPINC1 SERPINF2 SNCA TSG101	6 interacting genes: F2 KLK1 KLK2 KLK6 PLG SDC2
Entrez ID		5653	462
HPRD ID		04037	00122
Ensembl ID		ENSG00000167755	ENSG00000117601
Uniprot IDs		A0A024R4J8 Q92876	A0A024R944 P01008
PDB IDs		1GVL 1L2E 1LO6 3VFE 4D8N 5NX1 5NX3 6QFF 6QFG 6QFH 6QH9 6QHA 6QHB 6QHC 6SKB 6SKC 6SKD	1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?
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