PRSS3 and SERPINA1

Data Source:
HPRD (in vitro)

		PRSS3	SERPINA1
Description		serine protease 3	serpin family A member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Tertiary Granule Lumen	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Digestion Cobalamin Metabolic Process Antimicrobial Humoral Response Zymogen Activation Neutrophil Degranulation Endothelial Cell Migration	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating
Pathways		Alpha-defensins Cobalamin (Cbl, vitamin B12) transport and metabolism Neutrophil degranulation Antimicrobial peptides	Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation
Drugs		4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium 4-Hydroxybutan-1-Aminium 4-(Hydroxymethyl)Benzamidine Benzamidine Diamino-N-[3-(1,3,2-dioxaborolan-2-yloxy)propyl]methaniminium Guanidine-3-propanol [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine 1,3,2-Dioxaborolan-2-Ol	Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Mercaptoethanol Recombinant alpha 1-antitrypsin PPL-100 Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Alpha-1-antitrypsin (A1AT) deficiency
GWAS		Bipolar disorder ( 20351715) Hand grip strength ( 29691431) Refractive error ( 32231278) Triglycerides ( 30275531)	Alanine transaminase levels ( 28887542) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 22808956) Appendicular lean mass ( 33097823) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 29875488 28240269 23696881) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Height ( 28552196 29782485) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Large artery stroke ( 28265093) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Manganese levels ( 26025379) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Platelet count ( 27863252) Plateletcrit ( 32888494) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 31666285) Serum alpha-fetoprotein levels ( 31666285) Sucrose liking ( 31005972) Total cholesterol levels ( 30275531)
Interacting Genes		4 interacting genes: APP LINC00839 SERPINA1 TFPI	29 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GLP1R GSDMB KLK1 KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SLC13A1 SMAD4 VKORC1
Entrez ID		5646	5265
HPRD ID		06685	02463
Ensembl ID		ENSG00000010438	ENSG00000197249
Uniprot IDs		P35030 Q7Z5F4	E9KL23 P01009
PDB IDs		1H4W 2R9P 3L33 3L3T 3P92 3P95 4DG4 4U30 4U32 5C67 5JBT 5TP0 6BX8 6GFI	1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 6IAY 6ROD 7API 8API 9API
Enriched GO Terms of Interacting Partners?
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