PRSS1 and SERPINB8

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PRSS1	SERPINB8
Description		serine protease 1	serpin family B member 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Blood Microparticle	Extracellular Space Cytoplasm Cytosol Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Metal Ion Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Digestion Cobalamin Metabolic Process Extracellular Matrix Disassembly	Negative Regulation Of Endopeptidase Activity Epithelial Cell-cell Adhesion
Pathways		Activation of Matrix Metalloproteinases Cobalamin (Cbl, vitamin B12) transport and metabolism	Dissolution of Fibrin Clot
Drugs		2H-Benzimidazol-2-amine Bis(5-Amidino-Benzimidazolyl)Methane 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester CRA_17693 N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl Ester Hemi-Babim CRA_10991 Monoisopropylphosphorylserine [4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone Bis(5-Amidino-2-Benzimidazolyl)Methanone 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 5-Amidino-Benzimidazole Amylamine CRA_16847 Bis-Benzamidine CRA_17312 Zk-806450 [4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-Ammonium 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine CRA-9334 4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine CRA_10762 Aminomethylcyclohexane 2-(2-Hydroxy-Phenyl)-1h-Indole-5-Carboxamidine Benzylamine CRA_10655 (1R,2S)-2-Phenylcyclopropanaminium RPR131247 RWJ-56423 CRA_1802 CRA_10972 CRA_1801 [N-[N-(4-Methoxy-2,3,6-trimethylphenylsulfonyl)-L-aspartyl]-D-(4-amidino-phenylalanyl)]-piperidine Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 CRA_10433 Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone 4-Fluorobenzylamine RWJ-51084 1-(2-Amidinophenyl)-3-(Phenoxyphenyl)Urea ZK-806711 3,5-Diiodotyrosine (2S,3R)-2-[[4-(Tert-butylcarbamoyl)piperazine-1-carbonyl]amino]-6-(diaminomethylideneamino)-3-formylhexanoic acid bis(5-amidino-benzimidazolyl)methanone zinc CRA_11092 CRA_9785 Diminazene CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine Phosphorylisopropane Zinc;[amino-[2-[[5-[amino(azaniumylidene)methyl]benzimidazol-1-id-2-yl]methyl]benzimidazol-1-id-5-yl]methylidene]azanium [(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl Ester N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-Piperazine CRA_9076 N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic Acid CRA_23653 Cyclotheonamide A Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone Hydrate 4-Phenylbutylamine Phenethylamine 1-(4-Amidinophenyl)-3-(4-Chlorophenyl)Urea Aeruginosin 98-B 3-Phenylpropylamine RPR128515 ZK-805623 Imino[2-(2-oxo-1,2-dihydro-3-pyridinyl)-1H-benzimidazol-5-yl]methanaminium Benzo[B]Thiophene-2-Carboxamidine CRA_10656 CRA_9678 4-PIPERIDIN-4-YLBUTANAL 2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitol 2-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL 2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL 1,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitol Aprotinin diethyl [(1R)-1,5-diaminopentyl]boronate (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide 2-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDE 2-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATE 4-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDE 5-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acid +/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATE 2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE 2-Naphthalenesulfonic acid 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE Nafamostat Camostat
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779) Cancer ( 29299148) Meconium ileus in cystic fibrosis ( 30807572) Methadone dose in opioid dependence ( 28115739) Pancreatitis ( 23143602)	Airflow obstruction ( 22837378)
Interacting Genes		9 interacting genes: DEFA5 LINC00839 PTPN4 SERPINA1 SERPINB13 SERPINB8 SERPINF2 SPINK5 TST	5 interacting genes: CAP1 F10 F2 FURIN PRSS1
Entrez ID		5644	5271
HPRD ID		02039	03412
Ensembl ID		ENSG00000204983	ENSG00000166401
Uniprot IDs		P07477	A0A024R2B1 A0A1B0GU38 P50452
PDB IDs		1FXY 1TRN 2RA3 4WWY 4WXV
Enriched GO Terms of Interacting Partners?
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