PROS1 and C4BPA

Data Source:
HPRD (in vitro, in vivo)

		PROS1	C4BPA
Description		protein S	complement component 4 binding protein alpha
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Golgi Lumen Plasma Membrane Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Blood Microparticle
	Molecular Function	Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Leukocyte Migration	Complement Activation, Classical Pathway Response To Symbiotic Bacterium Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade	Regulation of Complement cascade
Drugs		Drotrecogin alfa Menadione Sodium tetradecyl sulfate Kappadione	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Inherited thrombophilia	Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Systemic lupus erythematosus ( 28714469)	Blood protein levels ( 29875488) C4b binding protein levels ( 20212171) Mean platelet volume ( 32888494 27863252) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		10 interacting genes: C4BPA C4BPB F10 F2 F5 F8 PROC RPSA TBK1 TYRO3	9 interacting genes: APCS BMPR2 FXYD6 GIT2 GTF2I LBP LRP1 PROS1 SMARCD1
Entrez ID		5627	722
HPRD ID		01473	00403
Ensembl ID		ENSG00000184500	ENSG00000123838
Uniprot IDs		A0A0S2Z4K3 A0A0S2Z4L3 P07225	P04003
PDB IDs		1Z6C	2A55 4B0F 5HYP 5HYT 5HYU 5HZP 5I0Q
Enriched GO Terms of Interacting Partners?
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