PRLR and GH1

Data Source:
HPRD (in vitro)

		PRLR	GH1
Description		prolactin receptor	growth hormone 1
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex	Extracellular Region Extracellular Space Endosome Lumen Collagen-containing Extracellular Matrix Growth Hormone Receptor Complex
	Molecular Function	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Prolactin Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding	Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding
	Biological Process	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Prolactin Signaling Pathway Oncostatin-M-mediated Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Leukemia Inhibitory Factor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cold-induced Thermogenesis	Positive Regulation Of Receptor Internalization Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Glucose Transmembrane Transport Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Nutrient Levels Response To Estradiol Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAP Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Bone Maturation
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Synthesis, secretion, and deacylation of Ghrelin Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		Somatotropin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		20 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 INSIG2 JAK2 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	4 interacting genes: GHR PRLR SHC1 TREM2
Entrez ID		5618	2688
HPRD ID		01457	00751
Ensembl ID		ENSG00000113494	ENSG00000259384
Uniprot IDs		P16471	B1A4G6 B1A4G7 P01241
PDB IDs		1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18	1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR 6QIO
Enriched GO Terms of Interacting Partners?
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