MAP2K6 and TAOK2

Data Source:
HPRD (in vivo, in vitro)

		MAP2K6	TAOK2
Description		mitogen-activated protein kinase kinase 6	TAO kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton	Nucleoplasm Nucleolus Cytoplasm Cytosol Actin Cytoskeleton Integral Component Of Membrane Axon Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Receptor Complex Dendritic Growth Cone Axonal Growth Cone
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Neuropilin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Response To Ischemia Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Positive Regulation Of Prostaglandin Secretion Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Sorbitol Negative Regulation Of Cold-induced Thermogenesis	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Protein Targeting To Membrane Apoptotic Process Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Axonogenesis Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Positive Regulation Of JNK Cascade Protein Autophosphorylation Focal Adhesion Assembly Neuron Projection Morphogenesis Stress-activated MAPK Cascade Basal Dendrite Morphogenesis Basal Dendrite Arborization
Pathways		NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling
Drugs		Fostamatinib	Dexfosfoserine Fostamatinib
Diseases
GWAS		Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Metabolic syndrome ( 31589552) Schizophrenia ( 28991256 25056061 29483656 30285260) Triglyceride levels ( 32203549 32154731) Waist circumference ( 31928498)
Interacting Genes		38 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K3 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6	13 interacting genes: CIDEB ELK1 KLHL12 KRTAP6-3 MAP2K3 MAP2K6 MAPRE3 MEGF10 RCHY1 TUBA1A TUBA4A TUBB USF1
Entrez ID		5608	9344
HPRD ID		03155	18147
Ensembl ID		ENSG00000108984	ENSG00000149930
Uniprot IDs		A0A024R8K3 A8K3Y2 P52564	Q9UL54
PDB IDs		2Y8O 3ENM 3FME 3VN9 5ETF
Enriched GO Terms of Interacting Partners?
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