MAPK9 and BCL2L11

Data Source:
HPRD (in vitro)

		MAPK9	BCL2L11
Description		mitogen-activated protein kinase 9	BCL2 like 11
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Mitochondrion Mitochondrial Outer Membrane Cytosol Endomembrane System Extrinsic Component Of Membrane Bcl-2 Family Protein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding	Protein Binding Microtubule Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation JNK Cascade JUN Phosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Tricellular Tight Junction Cellular Response To Cadmium Ion Positive Regulation Of Podosome Assembly Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	In Utero Embryonic Development B Cell Homeostasis B Cell Apoptotic Process Kidney Development Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myeloid Cell Homeostasis Apoptotic Process Meiosis I Cell-matrix Adhesion Spermatogenesis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Autophagy In Response To ER Overload Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Post-embryonic Animal Organ Morphogenesis Positive Regulation Of Apoptotic Process By Virus Thymocyte Apoptotic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To Amyloid-beta Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling FOXO-mediated transcription of cell death genes
Drugs		Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
Diseases
GWAS		Blood protein levels ( 30072576)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Dehydroepiandrosterone sulphate levels ( 21533175) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic granulomatosis with polyangiitis ( 31719529) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Primary sclerosing cholangitis ( 27992413 21151127) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 28869590) Urinary albumin-to-creatinine ratio ( 32600054) Vitiligo ( 27723757)
Interacting Genes		112 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BNIP5 C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 CYHR1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RASL10B RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZNF138 ZNF559 ZNHIT1	32 interacting genes: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BTK DTX2 DYNLL1 DYNLL2 FEM1C FGL1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D MKRN3 PEX19 RACK1 RIOK3 SMARCB1 TRIM2 UBQLN2 USHBP1 VDAC1 YWHAB
Entrez ID		5601	10018
HPRD ID		04206	04828
Ensembl ID		ENSG00000050748	ENSG00000153094
Uniprot IDs		D7R525 D7R526 P45984	A0A0A0MRE7 A0A0C4DH20 O43521
PDB IDs		3E7O 3NPC 7CML	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 2YQ7 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4A1U 4A1W 4B4S 4D2M 4QVF 4UF3 4YJ4 4ZIE 4ZIF 4ZIH 5AGW 5AGX 5C3G 5VWV 5VWW 5VWX 5VWY 5VWZ 5VX0 5VX2 5VX3 5WOS 6QFI 6RJP 6TQQ 6UA3 6UAB 6X8O
Enriched GO Terms of Interacting Partners?
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