PRKD1 and COPS2

Data Source:
BioGRID (enzymatic study)

		PRKD1	COPS2
Description		protein kinase D1	COP9 signalosome subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Metal Ion Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Apoptotic Process Inflammatory Response Golgi Organization Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sphingolipid Biosynthetic Process Cell Differentiation Regulation Of Protein Stability Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Golgi Vesicle Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Cellular Response To Hydroperoxide Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Integrin-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Sphingolipid de novo biosynthesis	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs		Bryostatin 1 Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28552196 23669352 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) California verbal learning test score ( 31596458) Carotid plaque burden ( 28282560) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood body mass index ( 26604143) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) IgM levels ( 28628107) Intelligence (MTAG) ( 29326435) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656 30285260) Spatial processing ( 31596458) Systolic blood pressure ( 30224653) Type 2 diabetes ( 30130595) Urinary sodium excretion ( 31409800) Waist circumference ( 28552196 25673412) Weight ( 28552196)	Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		34 interacting genes: ABL1 ADAP1 AKAP13 BTK C1QBP COPS2 COPS5 COPS7A EGFR EPAS1 HDAC5 HDAC7 IBTK IGF1R JUN KIDINS220 MAPK8 MAPK9 MT2A NOS1 PLCG1 PLCG2 PPP1R14A PRKCE PRKCH RACK1 SPRY2 SRC SYK TFAP2A TP53 USP28 YWHAQ YWHAZ	38 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446
Entrez ID		5587	9318
HPRD ID		05668	05146
Ensembl ID		ENSG00000184304	ENSG00000166200
Uniprot IDs		F8WBA3 Q15139	P61201 Q59EL2
PDB IDs			4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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