HR and TBL1X

Data Source:
BioGRID (two hybrid)

		HR	TBL1X
Description		HR lysine demethylase and nuclear receptor corepressor	transducin beta like 1 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Transcription Coregulator Activity Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone H3-K9 Demethylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Histone Deacetylation Regulation Of Lipid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases		Atrichia with papular lesions Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH)
GWAS		Obesity-related traits ( 23251661)	Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		35 interacting genes: AMMECR1 ATP23 C11orf1 C19orf54 CNFN CYSRT1 FAM168A GEMIN4 HDAC1 HDAC3 HDAC5 HMGB1 HOXA1 INCA1 KLHL20 KRTAP11-1 KRTAP13-2 KRTAP15-1 KRTAP3-1 KRTAP3-3 KRTAP6-3 MGAT5B PLA2G10 PRKCA RARA RARB RBP3 SPAG8 SPRY3 TBL1X TRIM27 TSC1 VDR YPEL3 ZMYND12	29 interacting genes: ARL3 CDC34 CORO2A CTNNB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I
Entrez ID		55806	6907
HPRD ID		03808	02183
Ensembl ID		ENSG00000168453	ENSG00000101849
Uniprot IDs		O43593	A0A024RBV9 O60907
PDB IDs			2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?
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