PRKCB and TOP2A

  • Data Source:
  • BioGRID (enzymatic study)
  • HPRD (in vitro, in vivo)

PRKCB

TOP2A

Description protein kinase C beta DNA topoisomerase II alpha
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Blood protein levels ( 30072576)
  • Bone mineral content ( 31790847)
  • Cadmium levels ( 26025379)
  • Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
  • Gut microbiota relative abundance (Dorea) ( 33208821)
  • Inflammatory bowel disease ( 28067908 23128233)
  • Lymphocyte counts ( 32888494)
  • Monocyte count ( 32888494)
  • Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
  • Primary biliary cholangitis ( 28062665)
  • Sleep duration ( 30531941)
  • Ulcerative colitis ( 28067908)
  • Hip circumference ( 25673412)
  • Hip circumference adjusted for BMI ( 25673412)
  • Neutrophil percentage of white cells ( 32888494)
Interacting Genes 87 interacting genes: AFAP1 ANXA2 ANXA7 BLVRA BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 FBXO7 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A GSK3B H1-0 H1-1 H1-5 H3C1 HABP4 HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LIG1 LMNB1 LST1 MAPK6 MAPT MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PTPA PTPN11 RACK1 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8 29 interacting genes: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 FBXO28 HDAC1 HDAC2 JUN MAPK1 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I XPO1 YWHAE
Entrez ID 5579 7153
HPRD ID 01499 00536
Ensembl ID ENSG00000166501 ENSG00000131747
Uniprot IDs P05771 P11388
PDB IDs 2I0E 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE
Enriched GO Terms of Interacting Partners?
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