PKIB and PRKACB

Data Source:
HPRD (in vivo)

		PKIB	PRKACB
Description		cAMP-dependent protein kinase inhibitor beta	protein kinase cAMP-activated catalytic subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity	Magnesium Ion Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Capping Negative Regulation Of CAMP-dependent Protein Kinase Activity	Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Protein Kinase A Signaling Activation Of Protein Kinase A Activity High-density Lipoprotein Particle Assembly Negative Regulation Of Meiotic Cell Cycle Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways			PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Phosphonothreonine Fostamatinib
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) White blood cell count ( 32888494)	Breast cancer (male) ( 23001122) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: DYNLL1 E2F1 E2F3 KRTAP3-1 LY6D NLGN3 PIN1 PRKACA PRKACB	15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73
Entrez ID		5570	5567
HPRD ID		06075	01482
Ensembl ID		ENSG00000135549	ENSG00000142875
Uniprot IDs		Q9C010	A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694
PDB IDs
Enriched GO Terms of Interacting Partners?
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