WDR33 and PFN2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WDR33	PFN2
Description		WD repeat domain 33	profilin 2
Image
GO Annotations	Cellular Component	Fibrillar Center Collagen Trimer Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex	Cytoplasm Cytoskeleton Extracellular Exosome
	Molecular Function	RNA Binding	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Postreplication Repair Termination Of RNA Polymerase II Transcription MRNA Polyadenylation MRNA Export From Nucleus Spermatogenesis MRNA 3'-end Processing	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			Triglyme Pentaglyme
Diseases
GWAS		Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) White blood cell count ( 32888494)	Fish- and plant-related diet ( 32066663)
Interacting Genes		19 interacting genes: CDK4 EEF1G GIT1 KAT7 MIR19A MIR19B1 MIR34B MIR92A2 PFN2 PRMT1 RBM48 SH3GL3 TGFBR1 TP53 UBC UTP14A WWOX ZBTB16 ZHX1	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		55339	5217
HPRD ID		11680	01451
Ensembl ID		ENSG00000136709	ENSG00000070087
Uniprot IDs		Q9C0J8	P35080
PDB IDs		6BLY 6BM0 6DNH 6F9N 6FBS 6FUW 6URG 6URO	1D1J
Enriched GO Terms of Interacting Partners?
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