LIN7C and KCNJ12

Data Source:
HPRD (in vivo, in vitro)

		LIN7C	KCNJ12
Description		lin-7 homolog C, crumbs cell polarity complex component	potassium inwardly rectifying channel subfamily J member 12
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Membrane
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding	Inward Rectifier Potassium Channel Activity Protein Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane	Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Protein Homotetramerization Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Dofetilide Ranolazine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS		Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)	Adult body size ( 32376654) Body mass index ( 28892062 25673413) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)
Interacting Genes		11 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12 MPP2 MPP3 MPP7 PALS1 PALS2 YES1	17 interacting genes: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		55327	3768
HPRD ID		17279	09083
Ensembl ID		ENSG00000148943	ENSG00000184185
Uniprot IDs		Q9NUP9	Q14500
PDB IDs		3LRA
Enriched GO Terms of Interacting Partners?
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