ABCF3 and LAMTOR1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ABCF3	LAMTOR1
Description		ATP binding cassette subfamily F member 3	late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Lysosome Lysosomal Membrane Plasma Membrane Late Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Membrane Raft Extracellular Exosome Ragulator Complex Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity Cadherin Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Binding Molecular Adaptor Activity
	Biological Process	Defense Response To Virus	Regulation Of Cell Growth Regulation Of Receptor Recycling Endosome Organization Lysosome Organization Cell Cycle Arrest Regulation Of Cholesterol Esterification Regulation Of Cholesterol Efflux Endosomal Transport Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Lysosome Localization Cellular Protein Localization Cholesterol Homeostasis Neutrophil Degranulation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cholesterol Import Cellular Response To Amino Acid Stimulus
Pathways			Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Major depressive disorder ( 22472876) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		20 interacting genes: ACIN1 CCDC33 DLEU1 DNALI1 FBXO7 FCHSD2 HIRIP3 LAMTOR1 MDFI MOCS2 NOA1 PSME3 RBPMS SLC35E1 SPP1 TBPL1 THAP1 TOE1 TRIM14 TRIM27	7 interacting genes: ABCF3 CAPN1 CCDC90B CTAG1A CTAG1B EEF1A1 TRIM14
Entrez ID		55324	55004
HPRD ID		12404	07933
Ensembl ID		ENSG00000161204	ENSG00000149357
Uniprot IDs		A0A0S2Z5L1 Q9NUQ8	Q6IAA8
PDB IDs			5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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