PPP2R5E and CTNNA3

Data Source:
BioGRID (biochemical)

		PPP2R5E	CTNNA3
Description		protein phosphatase 2 regulatory subunit B'epsilon	catenin alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol	Cytosol Cytoskeleton Adherens Junction Fascia Adherens Lamellipodium
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Protein Binding Beta-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Protein Dephosphorylation Signal Transduction Regulation Of Protein Autophosphorylation Regulation Of Phosphoprotein Phosphatase Activity	Actin Filament Organization Cell Migration Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Response to antineoplastic agents ( 21659360) Systolic blood pressure ( 28135244) Triglyceride levels ( 32154731)	Adventurousness ( 30643258) Adverse response to drug ( 30420678) Asthma (toluene diisocyanate-induced) ( 19187332) Bronchopulmonary dysplasia ( 23897914) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries ( 23064961) Diffusing capacity of carbon monoxide ( 30694715) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Essential tremor ( 27797806) General risk tolerance (MTAG) ( 30643258) Household income (MTAG) ( 31844048) Lung function (FVC) ( 24023788) Metabolite levels ( 23823483) Metabolite levels (Pyroglutamine) ( 23934736) Mitochondrial DNA copy number ( 30704525) Nickel levels ( 26025379) Nicotine dependence ( 17158188) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Optic disc area ( 28073927) Psoriatic arthritis ( 26626624) Pulse pressure ( 27841878) Schizophrenia (cytomegalovirus infection interaction) ( 23358160) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878)
Interacting Genes		20 interacting genes: APP BHLHB9 BHLHE41 CHEK2 CLOCK CRY1 CRY2 CSNK1E CSNK2B DELEC1 DOCK9 ENO1 FBXW11 PPP1CA PPP2CA PPP2R1B RACGAP1 RORC SGO1 SMAD9	68 interacting genes: AKAP9 ATP23 BLOC1S2 BLZF1 C17orf50 CCDC183 CCDC33 CDSN CENPS-CORT CKMT1A CKMT1B CMC2 COG4 CRX CTNNB1 DISC1 ECSIT EID2B EPS8 FAM110A FAM161A FAM161B FAM9A FBXO28 FERD3L GINS3 GNB1 HDX HOMEZ JUP KATNAL1 LASP1 MARCHF7 MBD3L1 MSRA MYOG NAB2 NDUFB7 OIP5 ORC2 PAX6 PLAGL2 PNMA1 PNMA5 POU6F2 PPARA PRR5 REL RIPPLY1 RPS6KA5 SERTAD2 SPATS1 STMN2 TASOR2 TLX3 TNNI1 TNNI2 TRIM54 TXNRD3 USHBP1 VIP ZG16 ZNF19 ZNF426 ZNF474 ZNF552 ZNF620 ZNF662
Entrez ID		5529	29119
HPRD ID		09040	09639
Ensembl ID		ENSG00000154001	ENSG00000183230
Uniprot IDs		Q16537	A8K141 Q8WW10 Q9UI47
PDB IDs
Enriched GO Terms of Interacting Partners?
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