PPP2R1B and CRY2

Data Source:
BioGRID (two hybrid)

		PPP2R1B	CRY2
Description		protein phosphatase 2 scaffold subunit Abeta	cryptochrome circadian regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm Protein Serine/threonine Phosphatase Complex Membrane Raft Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding FAD Binding
	Biological Process	Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Apoptotic Process Involved In Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation	Circadian Clock
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red blood cell count ( 32888494)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		40 interacting genes: AKAP9 ANXA5 BHLHE41 BSG CDK1 CDK4 CEP43 CFTR CLOCK CRY1 CRY2 CSNK2B DELEC1 EEF2 FBXW11 HDAC1 HSPD1 JAK2 MCM3 PARK7 PPP2CA PPP2R2A PPP2R3B PPP2R5C PPP2R5D PPP2R5E PRDX1 PRDX2 RAB11A RAB18 RAB7A RALA RELA RORC SET SGO1 SGO2 STRN STRN3 UNC5B	50 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 CYSRT1 DELEC1 EZH2 KLHL6 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP19-6 KRTAP4-2 KRTAP5-1 KRTAP5-2 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-8 LMNA MID1 MTUS2 NADK NBPF19 NOTCH2NLA NPAS2 PDE9A PER1 PER2 PER3 PICK1 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGER4 SBK3 SDCBP2 STK11 TIMELESS TRAF1 TRAF2 TTC1 VWC2 XRN2 ZBTB42
Entrez ID		5519	1408
HPRD ID		04384	07226
Ensembl ID		ENSG00000137713	ENSG00000121671
Uniprot IDs		P30154	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs
Enriched GO Terms of Interacting Partners?
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