DARS2 and AOC3

Data Source:
BioGRID (two hybrid)

		DARS2	AOC3
Description		aspartyl-tRNA synthetase 2, mitochondrial	amine oxidase copper containing 3
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix	Cytoplasm Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus Cell Surface Integral Component Of Membrane
	Molecular Function	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Amine Oxidase Activity Identical Protein Binding Protein Heterodimerization Activity Quinone Binding Tryptamine:oxygen Oxidoreductase (deaminating) Activity Aminoacetone:oxygen Oxidoreductase(deaminating) Activity Aliphatic-amine Oxidase Activity Phenethylamine:oxygen Oxidoreductase (deaminating) Activity
	Biological Process	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Xenobiotic Metabolic Process Inflammatory Response Cell Adhesion Amine Metabolic Process Response To Antibiotic Negative Regulation Of Primary Amine Oxidase Activity
Pathways		Mitochondrial tRNA aminoacylation	Phase I - Functionalization of compounds
Drugs		Aspartic acid	Phenelzine Hydralazine 6-hydroxydopa quinone
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		15 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	13 interacting genes: ARL13B CLDN9 CPLX4 CREB3L1 DARS2 FNDC9 HSD17B13 LMNA MYBPC2 PRRG4 SGTA STX1A VAV1
Entrez ID		55157	8639
HPRD ID		07677	04770
Ensembl ID		ENSG00000117593	ENSG00000131471
Uniprot IDs		Q6PI48 Q9H9J7	Q16853 Q9UEU7
PDB IDs		4AH6	1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY
Enriched GO Terms of Interacting Partners?
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