BANK1 and ITPR2

Data Source:
HPRD (in vivo)

		BANK1	ITPR2
Description		B cell scaffold protein with ankyrin repeats 1	inositol 1,4,5-trisphosphate receptor type 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Tyrosine Kinase Binding	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Calcium Ion Transmembrane Transporter Activity Phosphatidylinositol Binding Ion Channel Binding Inositol 1,4,5 Trisphosphate Binding Scaffold Protein Binding
	Biological Process	Response To Bacterium Negative Regulation Of Interleukin-6 Production B Cell Activation Positive Regulation Of MAPK Cascade Negative Regulation Of Translational Initiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of B Cell Activation Negative Regulation Of Protein Kinase B Signaling	Response To Hypoxia Signal Transduction Platelet Activation Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To CAMP Cellular Response To Ethanol Regulation Of Cardiac Conduction
Pathways			PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine
Diseases
GWAS		Adventurousness ( 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 22763476) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 28165464 26956414) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 30224653) General cognitive ability ( 29844566) Gut microbiota (beta diversity) ( 27723756) Hand grip strength ( 29691431) Hypertension ( 31879980) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean platelet volume ( 32888494 27863252) Refractive error ( 32231278) Schizophrenia ( 29483656) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 27399966 18204447 23273568 26502338 28714469) Systolic blood pressure ( 30578418)	Amyotrophic lateral sclerosis ( 17827064) Birth weight ( 31043758 27680694) BRCA1/2-negative high-risk breast cancer ( 30323354) Heel bone mineral density ( 30598549) Kashin-Beck disease ( 25303641) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lymphocyte counts ( 32888494) Major depressive disorder ( 27479909) Male-pattern baldness ( 27182965) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Refractive error ( 32231278) Renal cell carcinoma ( 31231134 22010048) Smooth-surface caries ( 24556642) Type 2 diabetes ( 30054458 30297969) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		4 interacting genes: ITPR1 ITPR2 LYN TRAF6	5 interacting genes: BANK1 LINC01554 PRKACA TRPC1 TRPC4
Entrez ID		55024	3709
HPRD ID		09819	02536
Ensembl ID		ENSG00000153064	ENSG00000123104
Uniprot IDs		Q8NDB2	Q14571
PDB IDs
Enriched GO Terms of Interacting Partners?
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