PHIP and TUBB3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHIP	TUBB3
Description		pleckstrin homology domain interacting protein	tubulin beta 3 class III
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GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Microtubule Lamellipodium Filopodium Axon Dendrite Growth Cone Extracellular Exosome
	Molecular Function	Insulin Receptor Binding Protein Binding Lysine-acetylated Histone Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Netrin Receptor Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Cell Shape Regulation Of Cell Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Axon Guidance Netrin-activated Signaling Pathway Dorsal Root Ganglion Development
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases			Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Diastolic blood pressure ( 27841878 27618448) Intelligence (MTAG) ( 29326435) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Mean arterial pressure ( 27618448) SjÃ¶gren's syndrome ( 24097067) Systolic blood pressure ( 27841878 30578418)	Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)
Interacting Genes		3 interacting genes: IRS1 STMN4 TUBB3	34 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		55023	10381
HPRD ID		10152	04044
Ensembl ID		ENSG00000146247	ENSG00000258947
Uniprot IDs		Q8WWQ0	Q13509 Q53G92
PDB IDs		3MB3 5ENB 5ENC 5ENE 5ENF 5ENH 5ENI 5ENJ 5RJI 5RJJ 5RJK 5RJL 5RJM 5RJN 5RJO 5RJP 5RJQ 5RJR 5RJS 5RJT 5RJU 5RJV 5RJW 5RJX 5RJY 5RJZ 5RK0 5RK1 5RK2 5RK3 5RK4 5RK5 5RK6 5RK7 5RK8 5RK9 5RKA 5RKB 5RKC 5RKD 5RKE 5RKF 5RKG 5RKH 5RKI 5RKJ 5RKK 5RKL 5RKM 5RKN 5RKO 5RKP 5RKQ 5RKR 5RKS 5RKT 5RKU 5RKV 5RKW 5RKX 5RKY	5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL
Enriched GO Terms of Interacting Partners?
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