PGPEP1 and UBE2E3

Data Source:
BioGRID (two hybrid)

		PGPEP1	UBE2E3
Description		pyroglutamyl-peptidase I	ubiquitin conjugating enzyme E2 E3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytosol
	Molecular Function	Pyroglutamyl-peptidase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Proteolysis	Protein Polyubiquitination Protein Ubiquitination Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 26961502 28892062 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronotype ( 30696823) Coronary artery disease ( 29212778) Gastroesophageal reflux disease ( 31527586) Growth differentiation factor-15 levels ( 29628937 22997280) Growth differentiation factor-15 levels (conditioned on rs888663) ( 29628937) Hand grip strength ( 29691431) Medication use (beta blocking agents) ( 31015401) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Periodontitis (Mean PAL) ( 24024966) Systemic lupus erythematosus ( 26606652)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Lymphocyte counts ( 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sweet taste preference ( 32572145) White blood cell count ( 27863252)
Interacting Genes		4 interacting genes: AQP1 NTAQ1 UBE2E2 UBE2E3	95 interacting genes: ACVR1 ARID3A ARIH2 ARRDC3 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DAZAP2 DTX3 DTX3L DZIP3 H3C1 H4C1 HERC4 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA OTUB1 PGPEP1 PICK1 PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TTC3 UBA1 UBC UBOX5 UFM1 WBP2 WWP2 ZNF746 ZNRF1 ZNRF4
Entrez ID		54858	10477
HPRD ID		07141	05000
Ensembl ID		ENSG00000130517	ENSG00000170035
Uniprot IDs		Q9NXJ5 S4R2Y9 U3KQ24	Q969T4 R4GNG6
PDB IDs
Enriched GO Terms of Interacting Partners?
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