CTSA and SGMS2

Data Source:
BioGRID (two hybrid)

		CTSA	SGMS2
Description		cathepsin A	sphingomyelin synthase 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Lumenal Side Of Lysosomal Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Golgi Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity	Ceramide Phosphoethanolamine Synthase Activity Protein Binding Kinase Activity Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity
	Biological Process	Proteolysis Glycosphingolipid Metabolic Process Intracellular Protein Transport Regulation Of Protein Stability Neutrophil Degranulation Regulation Of Catalytic Activity Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy	Sphingomyelin Biosynthetic Process Phosphorylation Sphingolipid Biosynthetic Process Regulation Of Bone Mineralization Ceramide Biosynthetic Process Ceramide Phosphoethanolamine Biosynthetic Process
Pathways		Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation	Sphingolipid de novo biosynthesis
Drugs
Diseases		Galactosialidosis
GWAS			Metabolite levels ( 23823483) Monoclonal gammopathy of undetermined significance ( 30737484)
Interacting Genes		45 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MFSD14B MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC18A1 SLC30A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2	6 interacting genes: CTSA GPX8 LMNA LPAR3 VAMP1 ZFPL1
Entrez ID		5476	166929
HPRD ID		02020	11323
Ensembl ID		ENSG00000064601	ENSG00000164023
Uniprot IDs		B4E324 P10619 X6R5C5 X6R8A1	A0A024RDH4 Q8NHU3
PDB IDs		1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?
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