PDP1 and CBFA2T2

Data Source:
BioGRID (two hybrid)

		PDP1	CBFA2T2
Description		pyruvate dehydrogenase phosphatase catalytic subunit 1	CBFA2/RUNX1 partner transcriptional co-repressor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity	Negative Regulation Of Transcription By RNA Polymerase II Transcription, DNA-templated Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Intestinal Epithelial Cell Differentiation
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex
Drugs
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Height ( 28552196) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 PDHA1 PRKCD SIRT3	34 interacting genes: APP ATN1 ATXN1L BAG4 CBFA2T3 CBFB CEP83 FBXL19 GTF2E1 ID3 KIFC3 KRTAP13-2 LBP MAGEA6 MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 PHAF1 PRDM14 PRDM6 RERE RUNX1 SIKE1 SIN3A SORBS3 TAL2 TCF4 TCP1 ZC2HC1A ZNF652
Entrez ID		54704	9139
HPRD ID		16185	04721
Ensembl ID		ENSG00000164951	ENSG00000078699
Uniprot IDs		A0A024R9C0 Q6P1N1 Q9P0J1	O43439
PDB IDs
Enriched GO Terms of Interacting Partners?
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