RRN3 and EIF3L

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		RRN3	EIF3L
Description		RRN3 homolog, RNA polymerase I transcription factor	eukaryotic translation initiation factor 3 subunit L
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	RNA Polymerase I Core Binding RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity	RNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Neuron Projection Development	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Viral Translational Termination-reinitiation
Pathways		RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Fruit consumption ( 32066663) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Triglyceride levels ( 32154731)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		10 interacting genes: CCNE1 CDK2 EIF3L MYO1C POLR1A POLR1B PPP2R2A TAF1A TAF1B TAF1C	12 interacting genes: DNM2 EIF3D EIF3E EIF3K ERCC6 HRAS POLR1B PPP1R18 RGS2 RRN3 SMAD2 XRN2
Entrez ID		54700	51386
HPRD ID		12004	10932
Ensembl ID		ENSG00000085721	ENSG00000100129
Uniprot IDs		B7ZB55 F5H148 Q9NYV6	Q9Y262
PDB IDs			3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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