MED1 and GATA6

Data Source:
HPRD (in vitro)

		MED1	GATA6
Description		mediator complex subunit 1	GATA binding protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding LBD Domain Binding Ubiquitin Protein Ligase Activity Promoter-specific Chromatin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Protein Import Into Nucleus Androgen Biosynthetic Process Brain Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Regulation Of Lipid Metabolic Process Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Enucleate Erythrocyte Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Liver Development Sebaceous Gland Cell Differentiation Regulation Of Antimicrobial Humoral Response Outflow Tract Septum Morphogenesis Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Regulation Of Transcription By RNA Polymerase II Phospholipid Metabolic Process Endodermal Cell Fate Determination Blood Coagulation Male Gonad Development Cardiac Muscle Hypertrophy In Response To Stress Epithelial Cell Differentiation Response To Retinoic Acid Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Transforming Growth Factor Beta2 Production Tube Morphogenesis Response To Drug Negative Regulation Of Apoptotic Process Response To Estrogen Cellular Protein Metabolic Process Cell Fate Commitment Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Formation Smooth Muscle Cell Differentiation Positive Regulation Of Cardioblast Differentiation Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Lung Saccule Development Club Cell Differentiation Type II Pneumocyte Differentiation Intestinal Epithelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Response To Growth Factor Positive Regulation Of Cell Cycle Arrest Cellular Response To Gonadotropin Stimulus Cellular Response To Hypoxia Cellular Response To BMP Stimulus Skin Epidermis Development Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Transforming Growth Factor Beta Activation Negative Regulation Of Sebum Secreting Cell Proliferation
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Generic Transcription Pathway Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression	Surfactant metabolism Factors involved in megakaryocyte development and platelet production
Drugs		Becocalcidiol
Diseases
GWAS		Asthma ( 31619474) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Lung function (FVC) ( 30061609) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 20228799)	Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) LDL cholesterol ( 25961943) Lung function (FEV1/FVC) ( 30804560) Resting heart rate ( 27798624) Severe progression in rheumatoid arthritis ( 29065906) Tuberculosis ( 20694014)
Interacting Genes		46 interacting genes: AKAP9 AR BRCA1 CASK CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MAPK3 MDM2 MED12 MED14 MED25 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RBM5 RORA RPA2 RXRA SREBF1 TET2 THRA THRB TP53 VDR YWHAH YWHAQ	7 interacting genes: CRIP2 EP300 HHEX KLF2 KPNA3 MED1 NKX2-1
Entrez ID		5469	2627
HPRD ID		05055	09043
Ensembl ID		ENSG00000125686	ENSG00000141448
Uniprot IDs		Q15648	Q92908
PDB IDs		1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W0G 3W0H 3W0I 3W0J 3W5P 3W5Q 3W5R 3W5T 3WT5 3WT6 3WT7 3WTQ 4YNK 5AWJ 5AWK 5B41 5B5B 5GIC 5GID 5GIE 5XPM 5XPN 5XPO 5XPP 5XUQ 5XZF 5XZH 5ZWE 5ZWF 5ZWH 5ZWI 6D94 6JEZ 6K5O 6ONJ
Enriched GO Terms of Interacting Partners?
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