DDX49 and MIR140

Data Source:
BioGRID (unspecified method)

		DDX49	MIR140
Description		DEAD-box helicase 49	microRNA 140
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Space
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding	RNA Polymerase II Complex Binding MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	RRNA Processing Positive Regulation Of Cell Growth Regulation Of RRNA Stability	Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of BMP Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Gene Silencing By MiRNA Defense Response To Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Vascular Endothelial Growth Factor Production Cellular Response To Amyloid-beta Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 26252872) Cerebrospinal P-tau181p levels ( 26252872)	Body mass index ( 26426971)
Interacting Genes		11 interacting genes: APP HAP1 MIR1-2 MIR138-2 MIR140 MIR15A MIR199A1 MIR214 PAGE1 PSMB2 STX1A	68 interacting genes: ADARB1 AIMP1 APOBEC3B C1QBP CELF1 CELF2 CRTAP CSTF1 DARS1 DDX1 DDX21 DDX3X DDX49 EIF2AK2 EPRS1 FAM98A FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 NOL6 NONO NUDT21 PDCD11 PIKFYVE PIP5K1A PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM14 RTCB SF3B1 SF3B3 SFPQ SYNCRIP TAF15 TRA2A TRA2B UPF1 UTP20 YBX1 YBX3
Entrez ID		54555	406932
HPRD ID		10864
Ensembl ID		ENSG00000105671	ENSG00000208017
Uniprot IDs		Q9Y6V7
PDB IDs
Enriched GO Terms of Interacting Partners?
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