GAR1 and SMN2

Data Source:
HPRD (in vivo, in vitro)

		GAR1	SMN2
Description		GAR1 ribonucleoprotein	survival of motor neuron 2, centromeric
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Fibrillar Center Nucleoplasm Telomerase Holoenzyme Complex Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Perikaryon Gemini Of Coiled Bodies
	Molecular Function	RNA Binding Protein Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	SnoRNA Guided RRNA Pseudouridine Synthesis Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Nervous System Development Import Into Nucleus
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol	snRNP Assembly
Drugs			Nusinersen
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		3 interacting genes: NEAT1 SMN1 SMN2	36 interacting genes: BLOC1S6 BYSL CHTOP DDX20 DHX9 EHHADH FAM9B FBL FNDC11 GAR1 GEMIN2 HNRNPUL1 IQUB KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 MAGED1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNU13 SPANXN2 TIAL1 USP9X VPS28
Entrez ID		54433	6607
HPRD ID		07569	09036
Ensembl ID		ENSG00000109534	ENSG00000205571
Uniprot IDs		Q9NY12	B4DP61 E7EQZ4 Q16637
PDB IDs			1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?