POMC and NRDC

Data Source:
HPRD (in vitro)

		POMC	NRDC
Description		proopiomelanocortin	nardilysin convertase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen	Mitochondrion Cytosol Cell Surface
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Metalloendopeptidase Activity Protein Binding Metal Ion Binding Epidermal Growth Factor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion	Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity Negative Regulation Of Cold-induced Thermogenesis
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production
Drugs		Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		28 interacting genes: ABI2 APP ATP6V0D2 BHLHA9 C1orf109 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN	6 interacting genes: CALCA H3C14 HBEGF NLGN3 PDYN POMC
Entrez ID		5443	4898
HPRD ID		01462	04036
Ensembl ID		ENSG00000115138	ENSG00000078618
Uniprot IDs		P01189	G3V1R5 O43847 Q6UUU9
PDB IDs		4XNH 4XPD 4Y49 6TUB
Enriched GO Terms of Interacting Partners?
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