POLR2J and SDCBP

Data Source:
BioGRID (two hybrid)

		POLR2J	SDCBP
Description		RNA polymerase II subunit J	syndecan binding protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm RNA Polymerase II, Core Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Nuclear Membrane Azurophil Granule Lumen Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	RNA Polymerase II Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding LRR Domain Binding Protein Dimerization Activity	Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Anchor Activity Identical Protein Binding Syndecan Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	Negative Regulation Of Receptor Internalization Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Chemical Synaptic Transmission Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Phosphorylation Neutrophil Degranulation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Ephrin signaling Neurofascin interactions RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Neutrophil degranulation
Drugs
Diseases
GWAS		Chronotype ( 30696823)	Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		17 interacting genes: AATF BAG6 CCDC153 CD14 LARP1B MYOG NTAQ1 OIP5 POLR1C POLR2C POLR2K SATB1 SDCBP SNAPC5 TENM1 TRAF4 VPS37C	307 interacting genes: ABI2 ANKRD33 ANKRD36B ANKRD40 ANP32B APIP ARFIP2 ARL6IP1 BCL2L15 BEND7 C11orf68 C1orf109 C1orf35 C2CD2L CABP5 CADM1 CADPS CALCOCO2 CALM1 CALM2 CALM3 CAV2 CBR3 CBY2 CCDC102B CCDC106 CD6 CD63 CDA CDC34 CDCP1 CDIPT CDKN2D CEP55 CEP85 CGGBP1 CHIC2 CHMP1A CLK2 CLK3 CMTM5 COX4I1 CRX CRYAA CRYAA2 CT45A1 CT45A10 CT45A3 CT45A5 CTBP2 CTDSP1 CUTC CYHR1 DCTD DCTPP1 DDX39B DERL3 DMC1 DNM2 DRAP1 DTNBP1 DYNLT1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A EIF5A2 ELAVL1 EMILIN3 ENOX1 ENTR1 EPHB2 ERICH2 EXOSC4 FADD FAM118A FAM118B FAM9A FAM9B FHL3 FHL5 FLAD1 FOXP2 FTH1 FTL GET4 GGPS1 GKAP1 GNMT GOLT1B GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRM2 GRM3 GRM7 GRXCR1 GSC2 GSG1 HEXIM2 HHAT HIVEP1 HMBOX1 HMGB3 HNRNPC HOMER3 HOMEZ HOXA1 HOXA7 HPRT1 HSBP1 HSF2BP HUS1 ID3 IGFBP6 IHO1 IKZF1 IL5RA INO80E KATNBL1 KCNH1 KCNJ2 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRT14 KRTAP1-3 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDB2 LDHB LDOC1 LEPROTL1 LGALS2 LSM6 LURAP1L LZTFL1 MAD2L1 MAPK9 MAPRE3 MATN4 MBD3 MED4 MEOX1 MEOX2 MGLL MID2 MINDY3 MKRN1 MOBP MRFAP1 MRFAP1L1 MTUS2 MYBPC2 MYLIP N4BP3 NADK NAGK NAPB NECAB2 NF2 NFASC NKAPD1 NOTCH2NLA NT5C2 OCM ODAM OPTN OSTF1 PCBD1 PCYT1A PDCD6IP PDE4DIP PDE9A PDLIM4 PDZK1IP1 PFDN5 PHC2 PHF11 PIH1D2 PNMA1 PNMA2 POLR2J POLR3K PPARA PRPF38A PRPF40A PRR13 PSMB3 PSMC6 PSME2 PSTPIP1 PTEN PTPRJ PTS PUF60 PYCR3 RAB5A RALY RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9 RP9P RPIA RPL22 RPRD1A RPRM RPS26 RRM2 RRS1 RTL8B RTN1 RUNDC3A S100B SCG3 SCML1 SDC1 SDC2 SDC4 SDCBP2 SEPTIN1 SEPTIN3 SET SFT2D1 SIAH1 SLC50A1 SLC6A5 SMARCA2 SNRPA SNX1 SOX4 SPANXN3 SREK1IP1 SRSF11 SRSF3 SRSF7 SSC5D SSNA1 STX1A SUB1 SULT1B1 SYNGR1 SYPL1 SYS1 TCF21 TCF4 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TKFC TLE5 TMCO2 TMEM17 TMEM239 TNFAIP8 TNFAIP8L3 TNKS TRAF5 TRARG1 TRIM27 TRIM32 TRIM38 TRIM54 TRIP13 TSN UBB UBC UBE2A UBE2K UBE2R2 ULK1 WASHC1 WASHC3 WASL WDR91 YIF1A ZBTB14 ZBTB8A ZCCHC10 ZCCHC17 ZMYND12 ZNF343 ZNF485 ZNF660 ZNF768 ZRANB1 ZSCAN23
Entrez ID		5439	6386
HPRD ID		16038	03741
Ensembl ID		ENSG00000005075	ENSG00000137575
Uniprot IDs		P52435	A0A024R7Z5 B4DHN5 G5EA09 O00560
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L	1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO 4Z33
Enriched GO Terms of Interacting Partners?
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