EXOSC9 and DDX39A

Data Source:
HPRD (two hybrid)

		EXOSC9	DDX39A
Description		exosome component 9	DExD-box helicase 39A
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck
	Molecular Function	3'-5'-exoribonuclease Activity RNA Polymerase II Activating Transcription Factor Binding RNA Binding Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding ATPase Activity Identical Protein Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Immune Response RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of Transcription By RNA Polymerase II Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		20 interacting genes: CHMP4B CSNK2A1 DDX39A DDX39B DIS3 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 HBS1L MPHOSPH6 MTREX PALS2 SUMO2 UBE2I ZDHHC17	14 interacting genes: CCL14 CHTOP DDX39B EXOSC9 HIPK2 HNRNPLL PTK2 RNF4 SARNP SAT1 SUMO2 TERF1 TERF2IP UBE2I
Entrez ID		5393	10212
HPRD ID		07315	10861
Ensembl ID		ENSG00000123737	ENSG00000123136
Uniprot IDs		B4DXG8 Q06265	O00148
PDB IDs		2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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