PLOD1 and MIR206

Data Source:
BioGRID (unspecified method)

		PLOD1	MIR206
Description		procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	microRNA 206
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Extracellular Exosome Catalytic Complex	RISC Complex
	Molecular Function	Iron Ion Binding Protein Binding Procollagen-lysine 5-dioxygenase Activity L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity	MRNA 3'-UTR Binding Protein Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Response To Hypoxia Protein O-linked Glycosylation Epidermis Development Peptidyl-lysine Hydroxylation Protein Phosphopantetheinylation	Positive Regulation Of Cell Fate Commitment Negative Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Gene Silencing By MiRNA Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Amyloid-beta Formation
Pathways		Collagen biosynthesis and modifying enzymes
Drugs		Ascorbic acid
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Nevo syndrome
GWAS		Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Moyamoya disease ( 29273593) Platelet count ( 27863252) Plateletcrit ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		40 interacting genes: MIR1-2 MIR10B MIR122 MIR128-2 MIR141 MIR143 MIR15A MIR15B MIR17 MIR18A MIR18B MIR199A2 MIR19A MIR19B1 MIR206 MIR20A MIR214 MIR221 MIR222 MIR29B1 MIR34A MIR34B MIR363 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I USP4	78 interacting genes: ADARB1 AIMP1 AQR C1QBP CELF1 CPSF1 CSTF1 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LCORL LIN28A LIN28B LRPPRC MARS1 MATR3 NOL4L NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SF3A3 SF3B1 SF3B2 SF3B3 SFPQ SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		5351	406989
HPRD ID		01086
Ensembl ID		ENSG00000083444	ENSG00000207604
Uniprot IDs		Q02809
PDB IDs
Enriched GO Terms of Interacting Partners?
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