PLEC and COL17A1

Data Source:
HPRD (in vitro, two hybrid)

		PLEC	COL17A1
Description		plectin	collagen type XVII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Cadherin Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Organization Hemidesmosome Assembly Regulation Of Immune Response
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly	Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)	Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Anti-saccade response ( 29064472) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fibrinogen levels ( 28107422 26561523) Height ( 31562340) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)	Cardiac hypertrophy ( 21348951)
Interacting Genes		24 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SNAPIN SPTA1 SPTAN1 SUMO2 UBC VIM	18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN
Entrez ID		5339	1308
HPRD ID		03180	00223
Ensembl ID		ENSG00000178209	ENSG00000065618
Uniprot IDs		Q15149	Q9UMD9
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I
Enriched GO Terms of Interacting Partners?
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