Description |
plasminogen activator, urokinase |
plasminogen |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- Amiloride
- 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide
- 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
- 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine
- 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine
- 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine
- 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- CRA_10655
- 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
- 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide
- 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide
- Benzamidine
- 4-Iodobenzo[B]Thiophene-2-Carboxamidine
- CRA_8696
- Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine
- 2-Amino-1H-benzimidazol-5-ol
- N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea
- 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
- Thieno[2,3-B]Pyridine-2-Carboxamidine
- 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide
- [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine
- Fibrinolysin
- 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine
- 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE
- N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE
- 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
- 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine
- (2R)-1-(2,6-dimethylphenoxy)propan-2-amine
- 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide
- 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
- 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE
- 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
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Diseases |
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GWAS |
- Blood protein levels ( 29875488)
- Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007)
- Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
- Crohn's disease ( 28067908)
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- Aging ( 22773346)
- Blood protein levels ( 29875488 28240269)
- Body mass index ( 26426971)
- Body mass index (age>50) ( 26426971)
- Body mass index x sex x age interaction (4df test) ( 26426971)
- Childhood ear infection ( 27182965 28928442)
- Cognitive decline rate in late mild cognitive impairment ( 26252872)
- Coronary artery disease ( 26343387 33020668)
- Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
- End stage renal disease x APOL1 genotype interaction ( 29885931)
- Giant cell arteritis ( 28041642)
- HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- LDL cholesterol levels in current drinkers ( 30698716)
- LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Lipoprotein (a) levels ( 26377243)
- Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334)
- Lp (a) levels ( 21900290)
- Myocardial infarction ( 26343387)
- Plasma plasminogen levels ( 25208887)
- Platelet count ( 32888494)
- Triglyceride levels ( 32203549)
- Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
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Interacting Genes |
25 interacting genes:
ADAM28
ALAS1
BTK
CEBPG
CTSB
CTSL
ELAVL1
F2
HGF
IGF2R
KAT8
LRP2
MYC
NID1
PDGFC
PLAT
PLAUR
PLG
SCAMP5
SERPINA5
SERPINB2
SERPINB6
SERPINE1
SERPINF2
ST14
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60 interacting genes:
ACTB
AMOT
ANXA2
APOH
ATP5F1B
C7
CDCP1
CHGA
CLEC3B
CP
CPB2
CXCL2
CYFIP2
ENO1
EP300
F10
F2R
F2RL1
F3
FN1
HMGB1
HRG
HSPA1A
HSPB1
HSPD1
IGF2
IGFBP3
KLK3
KNG1
LAMA1
LAMA3
MAPK14
MEP1A
MMP3
MMP7
MMP9
NGF
PAPPA
PCOLCE
PLAT
PLAU
PRDX4
PRNP
RAP2A
RBBP6
RUVBL1
S100A10
SERPINB13
SERPINB6
SERPINC1
SERPINE1
SERPINF2
SERPING1
SERPINI1
SMAD3
SMAD4
SPARC
TFPI2
THBS1
YTHDC1
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Entrez ID |
5328 |
5340 |
HPRD ID |
01883 |
01417 |
Ensembl ID |
ENSG00000122861
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ENSG00000122194
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Uniprot IDs |
A0A024QZM9
B4DNJ4
P00749
Q59GZ8
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P00747
Q5TEH5
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PDB IDs |
1C5W
1C5X
1C5Y
1C5Z
1EJN
1F5K
1F5L
1F92
1FV9
1GI7
1GI8
1GI9
1GJ7
1GJ8
1GJ9
1GJA
1GJB
1GJC
1GJD
1KDU
1LMW
1O3P
1O5A
1O5B
1O5C
1OWD
1OWE
1OWH
1OWI
1OWJ
1OWK
1SC8
1SQA
1SQO
1SQT
1U6Q
1URK
1VJ9
1VJA
1W0Z
1W10
1W11
1W12
1W13
1W14
2FD6
2I9A
2I9B
2NWN
2O8T
2O8U
2O8W
2R2W
2VIN
2VIO
2VIP
2VIQ
2VIV
2VIW
2VNT
3BT1
3BT2
3IG6
3KGP
3KHV
3KID
3M61
3MHW
3MWI
3OX7
3OY5
3OY6
3PB1
3QN7
3U73
4DVA
4DW2
4FU7
4FU8
4FU9
4FUB
4FUC
4FUD
4FUE
4FUF
4FUG
4FUH
4FUI
4FUJ
4GLY
4H42
4JK5
4JK6
4K24
4MNV
4MNW
4MNX
4MNY
4OS1
4OS2
4OS4
4OS5
4OS6
4OS7
4X0W
4X1N
4X1P
4X1Q
4X1R
4X1S
4XSK
4ZHL
4ZHM
4ZKN
4ZKO
4ZKR
4ZKS
5HGG
5WXF
5WXO
5WXP
5WXQ
5WXR
5WXS
5WXT
5XG4
5YC6
5YC7
5Z1C
5ZA7
5ZA8
5ZA9
5ZAE
5ZAF
5ZAG
5ZAH
5ZAJ
5ZC5
6AG2
6AG3
6AG7
6AG9
6JYP
6JYQ
6L04
6L05
6NMB
6XVD
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1B2I
1BML
1BUI
1CEA
1CEB
1DDJ
1HPJ
1HPK
1I5K
1KI0
1KRN
1L4D
1L4Z
1PK4
1PKR
1PMK
1QRZ
1RJX
2DOH
2DOI
2KNF
2L0S
2PK4
3UIR
4A5T
4CIK
4DCB
4DUR
4DUU
5HPG
5UGD
5UGG
6D3X
6D3Y
6D3Z
6D40
6OG4
6OQJ
6OQK
6Q1U
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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