PLAT and CRTC1

Data Source:
BioGRID (affinity chromatography technology)

		PLAT	CRTC1
Description		plasminogen activator, tissue type	CREB regulated transcription coactivator 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Nuclear Body Dendrite Neuronal Cell Body Glutamatergic Synapse
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding	Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway	Memory Viral Process Positive Regulation Of CREB Transcription Factor Activity Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Homotetramerization Energy Homeostasis Postsynapse To Nucleus Signaling Pathway Positive Regulation Of Dendrite Development Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Membrane Hyperpolarization
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Transcriptional activation of mitochondrial biogenesis Circadian Clock Circadian Clock
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Adult body size ( 32376654) Barrett's esophagus ( 24121790) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Body fat percentage ( 26833246) Body mass index ( 28552196 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined) ( 24121790) Esophageal adenocarcinoma ( 24121790) Estimated glomerular filtration rate ( 31152163) Gastroesophageal reflux disease ( 31527586) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Menarche (age at onset) ( 21102462 25231870)
Interacting Genes		27 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC VDAC1	4 interacting genes: CREB1 MAP3K1 SRPK2 YWHAG
Entrez ID		5327	23373
HPRD ID		01419	06339
Ensembl ID		ENSG00000104368	ENSG00000105662
Uniprot IDs		B4DN26 P00750	Q6UUV9
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?
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